peganum harmala l. extract reduces oxidative stress and improves symptoms in 6-hydroxydopamine-induced parkinson’s disease in rats

Authors

maryam rezaei razi herbal medicines research center, lorestan university of medical sciences

sima nasri department of biology, payam noor university

mehrdad roughani department of pharmacology, school of medicine, shahed university

zeinab niknami department of biology, payam noor university

abstract

parkinson’s disease is one of the most common neurodegenerative disorders. there are many documents about the effects of oxidative stress in parkinson’s disease etiology. angiotensin ii activates nadph dependent oxidases and causes superoxides formation. peganum harmala l. extract, which has angiotensin converting enzyme (ace) inhibitory effect, is considered to evaluate oxidative stress inhibition and parkinson's disease improvement. male rats weighting 200-250 g were divided into 5 groups: control, neurotoxin (injection of 6-hydroxydopamine into left hemisphere substantia nigra), peganum harmala's seedsaqueous extract (10 mg/kg) and captopril (5 mg/kg). peganum harmala and captopril were injected intraperitonealy -144, -120, -96, -72, -48, -24, -2, 4 and 24 h relative to 6-hydroxydopamine injection time. muscle stiffness, apomorphine induced unilateral rotation,amount of brain's protein oxidation and lipid peroxidation, ace activity and histology of substantia nigra were assayed in all groups. peganum harmala improved muscle stiffness and one-direction rotation behavior significantly. it also reduced brain's lipid and protein oxidation levels in neurotoxin-injected rats significantly. in peganum harmala group compared to control group, brain's ace activity was significantly inhibited. in histological study, peganum harmala prevented degeneration of dopaminergic neurons, too. in conclusion, aqueous extract of peganum harmala could prevent symptoms and reduced oxidative stress markers in rats with parkinson’s disease induced by 6-hydroxydopamine.

Upgrade to premium to download articles

Already have an account?login

similar resources

Peganum Harmala L. Extract Reduces Oxidative Stress and Improves Symptoms in 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats

Parkinson’s disease is one of the most common neurodegenerative disorders. There are many documents about the effects of oxidative stress in Parkinson’s disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation. Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhi...

full text

Peganum Harmala L. Extract Reduces Oxidative Stress and Improves Symptoms in 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats

full text

Peganum Harmala L. Extract Reduces Oxidative Stress and Improves Symptoms in 6-Hydroxydopamine-Induced Parkinson’s Disease in Rats

Parkinson's disease is one of the most common neurodegenerative disorders. There are many documents about the effects of oxidative stress in Parkinson's disease etiology. Angiotensin II activates NADPH dependent oxidases and causes superoxides formation. Peganum harmala L. extract, which has angiotensin converting enzyme (ACE) inhibitory effect, is considered to evaluate oxidative stress inhibi...

full text

Effects of Ferulago angulata Extract Against Oxidative Stress Induced by 6-hydroxydopamine in Rats

Background: Parkinson's disease is one of the prevalent degenerative diseases of the neural system. Oxidative stress, which has been recognized as the most important factor of Parkinson's disease, plays a main role in the death of neurons in this disease. Antioxidants have a proved role in the prevention of oxidative stress. Objective: Considering the presence of evidence regarding antioxid...

full text

Olive leaf extract reverses the behavioral disruption and oxidative stress induced by intrastriatal injection of 6-hydroxydopamine in rats

Introduction: Oxidative stress seems to play a critical role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD). Antioxidant compounds can deactivate and scavenge free radical. Olive leaves are considered as a useful source of phenolic compounds. Therefore, this study was designed to investigate the effects of methanolic olive leaf extract (OLE) on neurobehavioral act...

full text

effects of ferulago angulata extract against oxidative stress induced by 6-hydroxydopamine in rats

background: parkinson's disease is one of the prevalent degenerative diseases of the neural system. oxidative stress, which has been recognized as the most important factor of parkinson's disease, plays a main role in the death of neurons in this disease. antioxidants have a proved role in the prevention of oxidative stress. objective: considering the presence of evidence regarding antioxidant ...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}

Journal title:

iranian journal of pharmaceutical research

جلد ۱۵، شماره ۱، صفحات ۲۷۵-۲۸۱

Keywords

[ ' p e g a n u m h a r m a l a ' , ' p a r k i n s o n ’ s d i s e a s e ' , 6 , ' h y d r o x y d o p a m i n e ' , ' a n g i o t e n s i n r c o n v e r t i n g e n z y m e ' , ' r a t ' ]

Hosted on Doprax cloud platform doprax.com